Selected Research Publications:


Nicodemus-Johnson, J, Silic, S., Ghigliotti, L., Pisano, E. and Cheng, C.-H.C. (2011) Assembly of the antifreeze glycoprotein/ trypsinogen-like protease genomic lous in the Antarctic fish Dissostichus mawsoni (Norman) Genomics 98:194-201. pdf


Boron, I.,  Russo, R., Boechi, L.,  Cheng, C.-H.C., di Prisco, G., Estrin, D. A., Verde, C. and Nadra, A.D. (2011) Structure and dynamics of Antarctic fish neuroglobin assessed by computer simulations. IUBMB Life, 63(3): 206–213, 2011.

Deng, C., Cheng, C.-H.C. , Yea, H., He, X. and Chen, L. (2010) Evolution of an antifreeze protein by neofunctionalization under escape from adaptive conflict. Proc. Natl. Acad. Sci. U.S.A. 107:21593-21598. pdf Suppl Info


Zhuang, X. and Cheng, C.-H.C. (2010) ND6 gene "lost" and found: evolution of mitochondrial gene rearrangement in Antarctic notothenioids. Mol. Biol. Evol. 27:1391–1403. pdf, Suppl Info


Chen, Z., Ye, H., Zhou, L., Cheng, C.-H.C. , and Chen, L. (2010) A gene family-based method for interspecies comparisons of sequencing-based transcriptomes and its use in environmental adaptation analysis J. Genet. Genomics 37:205-218. pdf


Cheng, C.-H.C., di Prisco, G. and Verde,V.(2009) Cold-adapted Antarctic fish: The discovery of neuroglobin in the dominant suborder Notothenioidei. Gene 433: 100-101. pdf


Cheng, C.-H.C., di Prisco, G. and Verde,V. (2009) Is There an Answer? The "Icefish Paradox" - Which is the task of neuroglobin in Antarctic hemoglobin-less icefish? IUBMB Life 61:184-188.pdf


Chen,Z., Cheng,C.-H.C.,Zhang, J., Cao,L., Chen, L., Zhou, L., Jin, Y., Ye, H., Deng,C., Dai,Z., Xu,Q., Hu,P., Sun,S., Shen,Y. and Chen, L. (2008) Transcriptomic and genomic evolution under constant cold in Antarctic notothenioid fish. Proc. Natl. Acad. Sci. U.S.A. 103:10491-10496. pdf


Kiss, A.J. and Cheng, C.-H.C. (2008) Molecular diversity and genomic organisation of α, β and γ eye lens crystallins from the Antarctic toothfish Dissostichus mawsoni. Comp. Biochem. Physiol. Part D 3:155-171. pdf

Xu, Q., Cheng, C.-H.C., Hu, P., Hua, Y., Chen, Z., Cao, L., Chen, L., Shen, Y. and Chen, L. (2008) Adaptive evolution of hepcidins in Antarctic notothenioid fishes. Mol. Evol. Biol.25: 1099-1112. pdf


Near, T.J. and Cheng, C.-H.C. (2008) Phylogenetics of notothenioid fishes (Teleostei: Acanthomorpha): Inferences from mitochondrial and nuclear gene Sequences. Mol. Phylogenet. Evol. 47: 832-840. pdf


Cheng, C.-H.C. and Detrich, H.W.III. (2007) Molecular ecophysiology of Antarctic notothenioid fishes. Phil. Trans. Roy. Soc. Lond. Series B 362:2215-2232. pdf


Ghigliotti, L., Mazzei, F., Ozouf-Costaz ,C., Bonillo, C., Williams, R., Cheng, C.-H.C., and Pisano, E. (2007) The two giant sister species of the Southern Ocean, Dissostichus eleginoides and Dissostichus mawsoni, differ in karyotype and chromosomal pattern of ribosomal RNA genes. Polar Biol. 30:625-634. pdf


Cheng,C.-H.C., Cziko, P.A., and Evans, C.W. (2006) Non-Hepatic origin of notothenioid antifreeze reveals pancreatic synthesis as common mechanism in polar fish freezing avoidance.  Proc. Natl. Acad. Sci. U.S.A. 103:10491-10496. pdf


Cziko, P.A. and Cheng, C.-H.C. (2006) A new species of nototheniid (Perciformes: Notothenioidei) fish from McMurdo Sound, Antarctica. Copeia 4:752-759. pdf


Cziko,P.A., Evans, C.W.,Cheng, C.-H.C. and DeVries, A.L. (2006) Freezing resistance of antifreeze-deficient larval Antarctic fish.  J. Exp. Biol. 209:407-420.pdf


Evans, C.L., Pace, L., Cziko, P., Marsh, A.G., Cheng, C.-H.C. and DeVries, A.L. (2006) Metabolic energy utilization during development of Antarctic naked dragonfish (Gymnodraco acuticeps).   Polar Biol. 29:519-525.pdf


DeVries, A.L. and Cheng, C.-H.C. (2005)  Antifreeze proteins in polar fishes.  In Fish Physiology, Vol.22.  (Eds. A.P. Farrell and J.F. Steffensen), pp. 155-201, Academic Press, San Diego.


Evans, C.W., Cziko, P., Cheng, C.-H.C. and DeVries, A.L.(2005)  Spawning behaviour and early development in the naked dragonfish Gymnodraco acuticeps. Antarct. Sci. 17:319-327. pdf


Pointer, M.A., Cheng, C.-H.C., Bowmaker, J.K., Parry, Soto, N., J.W.L., Jeffery, G., Cowing, J.A, and Hunt, D.M. (2005) Adaptations to an extreme environment: retinal organisation and spectral properties of photoreceptors in Antarctic notothenioid fish. J. Exp. Biol. 208:2363-2376. pdf


Kiss, A.J., Mirarefi, A. Y., Ramakrishnan, S., Zukoski, C., DeVries, A.L., and Cheng, C.-H.C. (2004) Cold stable eye lens crystallins of the Antarctic nototheniid toothfish Dissostichus mawsoni (Norman). J. Exp. Biol. 207:4633-4649. pdf


Near, T.J., Pesavento, J.J., and Cheng, C.-H.C. (2004) Phylogenetic investigations of Antarctic notothenioid fishes (Perciformes: Notothenioidei) using complete gene sequences of the mitochonrial encoded 16S rRNA. Mol. Phylogenet. Evol. 32:"881-891. pdf


Cheng, C.-H.C. (2003) Freezing avoidance in polar fishes. In Encyclopedia of Life Support Systems (EOLSS) - Theme 6.73 Extremophiles (Ed. C. Gerday), developed under the auspices of the UNESCO, Eolss Publishers, U.K.


Romisch, K., Collie, N., Soto, N., Logue, J., Lindsay, M. Scheper, W., and Cheng, C.-H.C.  (2003) Protein translocation across the endoplasmic reticulum membrane in cold-adapted organisms. J Cell Sci. 116:2875-2883.pdf


Cheng, C.-H.C., Chen, L., Near, T.J., and Jin, Y. (2003)  Functional antifreeze glycoprotein genes in temperate-water New Zealand nototheniid fish infer an Antarctic origin. Mol. Biol. Evol. 20:1897-1909.pdf


Hunt, B., Hoefling, K., and Cheng, C.-H.C.  (2003) Annual warming episodes in seawater temperatures in McMurdo Sound in relationship to endogenous ice in notothenioid fish.  Antarct. Sci. 15:333-338. pdf


Near, T.J., Pesavento, J.J., and Cheng, C.-H.C.(2003)  Mitochondrial DNA, morphology, and the phylogenetic relationships of Antarctic icefishes (Notothenioidei: Channichthyidae).  Mol. Phylogenet. Evol. 28: 87-98. pdf


Ko, T.P., Robinson, H., Gao, Y.-G., Cheng, C.-H.C., DeVries, A.L., and Wang, A.H.-J.(2003)  The refined crystal structure of an eel pout Type III antifreeze protein RD1 at 0.62-A resolution reveals structural microheterogeneity of protein and solvation.  Biophys. J. 84:1228-1237.pdf


Cheng, C.-H.C. and DeVries, A.L.  (2002) Origins and evolution of fish antifreeze proteins.  In Molecular Aspects of Fish and Marine Biology Vol.1 - Monograph on Fish Antifreeze Proteins  (Eds. C. Hew and V. Ewart), pp. 83-108, World Sci. Press, New Jersey.


Lavalle, P., DeVries, A.L., Cheng, C.-H.C. and Ramsden, J.J. (2000) Direct observation of the interaction between antifreeze glycoproteins and hydrated hydroxylated surfaces. Langmuir 16:5785-5789. pdf


Cheng, C.-H.C.and L. Chen (1999) Evolution of an antifreeze glycoprotein. Nature 40: 443-444.pdf


Cheng, C.-H.C. (1998)  Origin and mechanism of evolution of antifreeze glycoproteins in polar fish.  In  Evolution of the Antarctic Ichthyofauna (Eds. G. di Prisco and E. Pisano), pp. 311-328, Springer-Verlag, Italy.


Cheng, C.-H.C. (1998) Evolution of the diverse antifreeze proteins.  Curr. Op. Genet. Develop. 8:715-720.  pdf


Chen, L. DeVries, A.L. and Cheng, C.-H.C. (1997a) Evolution of antifreeze glycoprotein gene from a trypsinogen gene in Antarctic notothenioid fish. Proc. Natl. Acad. Sci. USA 94:3811-3816.pdf


Chen, L., DeVries, A.L., and Cheng, C.-H.C. (1997b) Convergent evolution of antifreeze glycoproteins in Antarctic notothenioid fish and Arctic cod. Proc. Natl. Acad. Sci. USA 94:3817-3822.pdf


Cheng, C.-H. C.(1996) Genomic basis for antifreeze glycopeptide heterogeneity and abundance in Antarctic notothenioid fishes. In "Gene Expression and Manipulation in Aquatic Organisms", Soc. of Expt. Biol. Seminar Series 58 (Eds. S. Ennion and G. Goldspink), pp. 1-20. Cambridge University Press, U.K.


Wang, X., DeVries, A.L. and Cheng, C.-H. C. (1995)  Genomic basis of antifreeze peptide heterogeneity and abundance in an antarctic eel pout - gene structures and organization. Mol. Mar. Biol. Biotechnol. 4:135-147.


Wang, X., DeVries, A.L. and Cheng, C.-H. C. (1995)  Antifreeze peptide heterogeneity in an antarctic eel pout includes an unusually large major variant comprised of two 7 kDa type III AFPs linked in tandem.  Biochim. Biophys. Acta  1247:163-172. pdf


DeVries, A. L. and Cheng, C.-H. C.  (1992)  The role of antifreeze glycopeptides and peptides in the survival of cold water fishes.  In "Water and Life:  Comparative Analysis of Water relationships at the Organismic, Cellular, and Molecular Levels" (Eds. G.N. Somero,  C.B. Osmond, and C.L. Bolis), pp. 303-315, Springer-Verlag.


Cheng, C.-H.C. and DeVries, A.L. (1991) The role of antifreeze glycopeptides and peptides in the freezing avoidance of cold water fishes.  In “Life Under Extreme Conditions” (Ed. Guido di Prisco), Springer-Verlag, Berlin-Heidelberg, pp. 1-14.


Hsiao, K., Cheng, C.-H.C.,Fernandes, I.E., Detrich, H.W. and DeVries, A.L.(1990)  An antifreeze glycopeptide gene from the antarctic cod Notothenia coriiceps neglecta encodes a polyprotein of high peptide copy number.  Proc. Natl. Acad. Sci. 87:9265-9269. pdf


Knight, C.A., Cheng, C.-H.C. and DeVries, A.L. (1991)  Adsorption of alpha-helical antifreeze peptides on specific ice crystal planes. Biophysical J. 59:409-418.


Cheng, C.-H.C. and DeVries, A.L. (1989)  Structures of antifreeze peptides from the Antarctic eel pout, Austrolycichthys brachycepahlus.  Biochim. Biophy. Acta 997:55-64.pdf


Schrag, J.D., Cheng, C.-H.-C., Panico, M., Morris, H.R., and DeVries, A.L. (1987) Primary and secondary structure of antifreeze peptides from arctic and antarctic zoarcid fishes. Biochim. Biophys. Acta 915:357-370.pdf