CRITICA Distribution

CRITICA (Coding Region Identification Tool Invoking Comparative Analysis)
is a program for identifying the protein coding regions in DNA based on a
combination of evidence from dicodon usage frequencies and a comparative
analysis of the relative conservation of DNA sequence and their potential
protein products.

CRITICA is described in the paper:

     Badger, J. H., and Olsen, G. J.  1999.  CRITICA:  Coding region
     identification tool invoking comparative analysis.  Mol. Biol. Evol.
     16: 512-524.

For the time being, this directory  contains an unofficial release (1.0.5b)
of the program and documentation files that includes a bug fix for about 1/3
of the reading frames that run off the end of a contig (something that
matters more for partial genome projects than for completed genomes).

In general, the latest versions of CRITICA can be obtained from:

     http://www.math.uwaterloo.ca/~jhbadger/critica/

If anyone notices a version newer than 1.0.5 (01-Aug-2000) appearing at
Jonathan's site, please E-mail me so that I can remove this copy of the
program.

Gary

This file written and maintained by Gary J. Olsen (gary@phylo.life.uiuc.edu)