Speculative mechanism for the bc1 complex

<body> <center><img src="etp-model_annotated.gif"> </center> <p> The initial view is of the three subunits from a "functional" monomer, presented as a stereo pair for <a href="view-3d.html">"crossed-eye" viewing</a>. Coordinates from the Zhang et al. native complex from chicken heart mitochondrial complex have been supplemented by additional coordinates to provide the working model (see below). <p>The structures used in this animation are a composite from the sets of coordinates kindly made available by Dr. Ed Berry, of the bc<sub>1</sub>-complex from chicken heart mitochondria, and by Dr. S. Iwata, of the beef heart mitochondrial complex in P6<sub>5</sub>22 and P6<sub>5</sub> crystals. <p>The coordinates from the solved structures were supplemented with models for the quinone, quinol, and semiquinone substrates needed to show their involvement in the catalytic cycle. The composite file includes coordinates for the different components, in different configurations, involved in turnover of the complex. <p>A detailed explanation of the model is provided in the <a href="http://www.life.uiuc.edu/crofts/bc1_in_chime/etp_model_struc.html"> original Chime-based version</a>, which has extensive notes. <p>Click her for <a href="model_explained.html">an explanation of the model</a> <p>Click here for a Chime-based exploration of <a href="http://www.life.uiuc.edu/crofts/bc1_in_chime/dimer.html" target="_blank"> the complete chicken complex</a>. Click here for a <a href="http://www.life.uiuc.edu/crofts/bc1_in_chime/bcc.html" target="_blank">Chime tutorial on the structure/function interface</a>, based on the three catalytic subunits of a "functional" monomer <p>(The above Chime-based links will only work if you download and install <a href="http://www.mdli.com/downloads/chime.html"><img src="chinow.gif">the Chime plug-in</a> for Netscape). </body>