CaM Sequence Comparisons

A comparison of the primary structures of angiosperm, vertebrate and yeast calmodulin proteins. Sequences shown in the figure were deduced from the nucleotide sequences of Arabidopsis thaliana, human, and Saccharomyces cerevisiae cDNAs. They are displayed to show the sequence relationships of the four EF-hand domains; dashes indicate identical residues. Residues marked by an * indicate Ca²⁺-binding ligands. The residue marked D in the yeast sequence is a deletion introduced for alignment purposes. A caret (^) indicates a residue in plant calmodulins in which substitutions occur in >5% of the reported sequences. Lysine 115 (K115, marked in blue) is trimethylated in spinach and wheat and presumed to be similarly modified in other plant species.

Calmodulin sequences from the following plant and algal species (and their GenBank Accession Numbers) used in this comparison are as follows: A. thaliana (M38379, M38380, M73711, Z12022, D45848, Z12024); B. pilosa (X89890); B. juncea (M88307); B. napus (U10150); B. dioica (L14071); C. annuum (X97558, X98404, U83402); C. reinhardtii (M20729); D. carota (X59751); D. salina (U62865); F. sylvatica (X97612); G. max (L01430, L01431, L01432, L01433, L15359); H. annuus (U79736); H. vulgare (M27303); L. longiflorum (L18912, Z12839); L.esculentum (M67472); M. pyrifera (X85091); M. domestica (X60737); M. sativa (X52398); O. sativa (L18913, L18914, X65016, Z12827, Z12828); P. hybrida (M80831, M80832, M80836); P. patens (X90560); P. sativum (U13882); S. tuberosum (J04559, U20291, U20292, U20293, U20294, U20295, U20296, U20297); S. oleracea (A03024); T. aestivum (U48242, U48688, U48689, U48690, U48691, U48692, U48693, U49103, U49104, U49105); V. radiata (L20507, L20691, S81594); and Z. mays (X74490, X77396, X77397)

Return to the TOP of this page.