Chemistry & Biology, 9(10):1059-1072, 2002 The Chemical Biology of Apoptosis: Exploring Protein-Protein Interactions and the Life and Death of Cells with Small Molecules Huang Z. J. Autoimmunity, 18(2):169-179, 2002 An Organic CD4 Inhibitor Reduces the Clinical and Pathological Symptoms of Acute Experimental Allergic Encephalomyelitis. Edling A.E., Choksi S., Huang Z., Korngold R.   J. Biol. Chem., 277(20):17476-17485, 2002 Exploring the stereochemistry of CXCR4-peptide recognition and inhibiting HIV-1 entry with D-peptides derived from chemokines. Zhou N, Luo Z, Luo J, Fan X, Cayabyab M, Hiraoka M, Liu D, Han X, Pesavento J, Dong CZ, Wang Y, An J, Kaji H, Sodroski JG and Huang Z.   Blood, 99(9):3461-3464, 2002 Simultaneous disruption of the Bcl-2 and MEK/MAPK pathways sinergistically induces apoptosis in acute myelogenous leukemia. Milella M, Kornblau SM, Estrov Z, Konopleva M, Tari A, Schober WD, Carter B, Harris D, Leysath CL, Berestein GL, Sebolt-Leopold JS, Huang Z and Andreeff M.   Cancer Research, 62(2):466-471, 2002 Epothilone B analogue (BMS-247550)-mediated cytotoxicity through induction of Bax conformational change in human breast cancer cells. Yamaguchi H, Paranawithana SR, Lee MW, Huang Z, Bhalla KN and Wang HG. J. Biol. Chem., 276:42826-42833, 2001 Structural and functional characterization of human CXCR4 as a chemokine receptor and HIV-1 co-receptor by mutagenesis and molecular modeling studies. Zhou N, Luo Z, Luo J, Liu D, Hall JW, Pomerantz RJ and Huang Z.   Mini-Reviews in Medicinal Chemistry, 2:373-383, 2002 Structure, function and modulation of chemokine receptors: members of the G-protein-coupled receptor superfamily. Huang Z   Apoptosis, 6: 453-462, 2001 Synthetic peptides and non-peptidic molecules as probes of structure and function of Bcl-2 family proteins and modulators of apoptosis. Liu D, Huang Z.   J. Neuroimmunol., 112: 115-28, 2001 Effect of a cyclic heptapeptide based on the human CD4 domain 1 CC'-loop region on murine experimental allergic encephalomyelitis: inhibition of both primary and secondary responses. Edling AE, Choksi S, Huang Z and Korngold R.   Oncogene, 19, 6627-6631, 2000 Bcl-2 family proteins as targets for anticancer drug design Ziwei Huang   Current Opinion in Drug Discovery and Development,3: 565-574, 2000 Small molecule inhibitors of Bcl-2 function: modulators of apoptosis and promising anticancer agents Ziwei Huang Pharmacology & Therapeutics, 86: 201-215, 2000 Structural chemistry and therapeutic intervention of protein-protein interactions in immune response, HIV entry and apoptosis Ziwei Huang   Biochemistry, 39: 13545-13550, 2000 Structure-function study and anti-HIV activity of synthetic peptide analogs derived from viral chemokine vMIP-II Luo Z, Fan X, Zhou N, Hiraoka M, Luo J, Kaji H, and Huang Z*   Biochemistry, 39(13):3782-3787, 2000 A novel peptide antagonist of CXCR4 derived from the N-terminus of viral chemokine vMIP-II Naiming Zhou, Zhaowen Luo, Jiansong Luo, James W. Hall and Ziwei Huang*   Euro. J. Immunol. 30: 164-173, 2000 Molecular modeling and site-directed mutagenesis of CCR5 reveal residues critical for chemokine binding and signal transduction Zhou N, Luo Z, Hall JW, Luo J, Han X and Huang Z*   Tetrahedron Letters, 41: 6993-6996, 2000 Reactions of salicylaldehydes with alkyl cyanoacetates on the surface of solid catalysts: syntheses of 4H-chromene derivatives Yu N, Aramini JM, Germann MW and Huang Z*   J. Biol. Chem., 275: 36152-36157, 2000 Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway Srinivasula SM, Datta P, Fan XJ, Fernandes-Alnemri T, Huang Z and Alnemri ES   Proc. Natl. Acad. Sci. USA, 97(13):7124-7129, 2000 Structure-based discovery of a novel organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells Jia-Lun Wang, Dongxiang Liu, Zhi-Jia Zhang, Simei Shan, Xiaobing Han, Srinivasa M. Srinivasula, Carlo M. Croce, Emad S. Alnemri & Ziwei Huang*   Cancer Research, 60:1498-1502, 2000 Cell Permeable Bcl-2 Binding Peptides: A Chemical Approach to Apotosis Induction in Tumor Cells Jia-Lun Wang, Zhi-Jia Zhang, Swati Choksi, Simei Shan, Zhixian Lu, Carlo M. Croce, Emad S. Alnemri, Robert Korngold & Ziwei Huang*   J. Med. Chem., 43(2): 146-155, 2000 Structure-based Discovery of Small Molecule Inhibitors Targeted to Protein Tyrosine Phosphatase 1B Mauro Sarmiento, Li Wu, Yen-Fang Keng, Li Song, Zhaowen Luo, Ziwei Huang, Adam K. Yuan, and Zhong-Yin Zhang   Biochem. Biophy. Res. Comm. , 265(2):350-355, 1999 The roles of sidechain and backbone in protein structure probed with glycine- and sarcosine-rich synthetic leucine zipper peptides Daniel J. Butcher, Zhaowen Luo, and Ziwei Huang*   Biochem. Biophy. Res. Comm. , 263(3):691-695, 1999 The role of positively charged residues in CXCR4 recognition probed with synthetic peptides Zhaowen Luo, Naiming Zhou, Jiansong Luo, James W. Hall and Ziwei Huang*   Biochem. Biophy. Res. Comm. , 264(1):42-47, 1999 The attachment of C-terminus of SDF-1 enhances the biological activity of its N-terminal peptide Jiansong Luo, Zhaowen Luo, Naiming Zhou, James W. Hall and Ziwei Huang*   J. Biol. Chem., 274(18):12468-73, 1999 EC3, A Novel Heterdimeric Disintegrin from Echis Carinatus Venom, Inhibits a4 and a5 Integrins in an RGD-Independent Manner Cezary Marcinkiewicz, Juan J. Calvete, Mariola M. Macinkiewicz, Manfred Raida, Ziwei Huang, Roy R. Lobb and Stefan Niewiarowski   Experimental cell research, 250(1):22-32, 1999 Character of an antibody that can detect an activated IGF-I receptor in human cancers Michele Rubini, Consuelo D'Ambrosis, Sabrina Carturan, Gladya Yumet,Edison Catalano, Simei Shan, Ziwei Huang, Mario Criscuolo, Micol Pifferi and Renato Baserga   Journal of Cellular Physiology, 181:(1):124-35, 1999 Synthetic peptide sequence from the C-terminus of the insulin-like growth factor-I receptor that induces apoptosis and inhibition of tumor growth Krzysztof Reiss, Gladys Yumet,Simei Shan, Ziwei Huang,Emad Alnemri, Srinivasa M. Srinivasula,Jin Ying Wang,Andrea Morrione and Benato Baserga   Immunology Today19(10):455-462, 1998 CD4 dimerization and oligomerization: Implication for T-cell function and structure-based drug design Song Li, Takashi Satoh, Robert Korngold, and Ziwei Huang*   J. Biol. Chem. 273: 16442-16445, 1998 Identification of the CD8 DE Loop as a Surface Functional Epitope: Implication For MHC Class I Binding and CD8 Inhibitor Design Song Li, Swati Choksi, Simei Shan, Jimin Gao, Robert Korngold, and Ziwei Huang*   Biochem. Biophy. Res. Comm. 244: 732-736, 1998 Structural Studies of Peptide Fragments Derived from the HIV-1 Vpr Protein Zhowen Luo, Daniel J. Butcher, R. Murali, A. Srinivasan, Ziwei Huang*   J. Biol. Chem. (Communication), 273: 10107-10111, 1998 Generation of constitutively active recombinant caspase-3 and -6 by rearrangement of their subunits Srinivasa M. Srinivasula, Manzoor Ahmad, Marion MacFarlan, Zhaowen Luo, Ziwei Huang, Teresa Feranades-Alnemri, and Emad S. Alnemri   Biopolymer (Peptide Sci.) 43: 367-382, 1997 Immunoglobulin Superfamily Proteins: Structure, Mechanisms and Drug Discovery Ziwei Huang*, Song Li and Robert Korngold   Protein Engineer, 10(9) 1039-1045, 1997 Molecular Modeling of Interleukin-8 Receptor b and Analysis of the Receptor-ligand Interaction Zhaowen Luo, Daniel Butcher and Ziwei Huang*   FEBS Letters 409(2): 183-187, 1997 A Natural Motif Approach to Protein Design: A Synthetic Leucine Zipper Peptide Mimics the Biological Function of the Platelet Factor 4 Protein Daniel J. Butcher, M. Anna Kowalska, Song Li,Zhaowen Luo, Simei Shan, Zhixian Lu;, Stefan Niewiarowski, and Ziwei Huang ;*   Biochem. Biophy. Res. Comm. 240: 208-212, 1997 A Novel Class of Peptides That Induce Apoptosis and Abrogate Tumorigenesis in vivo Mariana Resnicoff*, Ziwei Huang, Debroski Herbert, David Abrham and Renato Baserga   Med. Chem. Res., 7(3): 137-150, 1997 Immunologlobulin Superfamily Proteins: Targets for Medical Chemistry Research Ziwei Huang*, Song Li and Robert Korngold   Proc. Natl. Acad. Sci. USA 94: 73-78, January 1997 A computer screening approach to immunoglobulin superfamily structures and interactions: Discovery of small non-peptidic CD4 inhibitors as novel immunotherapeutics Song Li, Jimin Gao, Takashi Satoh, Thea M. Friedman, Andrea E. Edling, UteKoch, Swati Choksi, Xiaobing Han, Robert Korngold, and Ziwei Huang*   J. Biol. Chem. 272: 12175-12180, 1997 Bioactive peptide design based on protein surface epitopes: a cyclic heptapeptide mimics CD4 domain 1 CC' loop and inhibits CD4 biological function Takashi Satoh, James M. Aramini, Song Li, Thea M. Friedman, Jimin Gao, Andrea E. Edling, Robert Townsend, Ute Koch, Swati Choksi, Markus W. Germann, Robert Korngold, Ziwei Huang