Ziwei Huang, Ph.D.
Associate Professor of
Biochemistry & Biophysics
Affiliate, Dept. of Chemistry
University of Illinois
302 Burrill Hall, MC-119
407 S Goodwin Ave.
Urbana, IL 61801
Tel: 217-265 0991
Fax: 217-265 0992
Email: z-huang@life.uiuc.edu
PLEASE NOTE THE ADDRESS CHANGE FOR DR. HUANG AND OUR LAB
We will be moving from Illinois to San Diego
on June 1, 2004. Here is our new contact address:
Ziwei Huang, Ph.D.
Professor and Director
Medicinal Chemistry & Drug Discovery Alliance
The Burnham Institute
10901 N. Torrey Pines Road
La Jolla, California 92037
Telephone: 858-713-9928
Fax: 858-713-9927
E-mail: ziweihuang@burnham.org
News: Multiple Research Positions
Research at the Interface of
Chemistry, Biology and Medicine
We are a diverse
group of people with different
backgrounds and skills in chemistry, structure, computer,
biology and medicine. However, we share two common
goals in our research: (1) exploring the fundamental
mechanisms of molecular recognition (such as
protein-protein and ligand-receptor interactions) involved
in biological processes; (2) translating such insights into
the design and discovery of novel therapeutic agents for
human diseases. To this end, we combine techniques in
synthetic chemistry, molecular modeling, structure
determination, molecular and cellular biology and clinical
medicine to advance our studies. As detailed in our recent
publications, we have applied this multi-disciplinary
approach to study the structure and function of proteins
involved in immune response, HIV entry and apoptosis and
developed a number of promising leads for combating
with cancer, HIV infection and immunological disorders
(one of these agents already in a Phase I human clinical
trial while others in active pre-clinical development).
These novel agents also provide powerful tools for our
ongoing research into the mechanisms of molecular
interactions and signal transduction mediated by their
macromolecular targets.
In the year of 2000, we moved from the city of
Philadelphia to this beautiful suburban campus at
Urbana-Champaign. Our newly renovated laboratories are located on the 3rd floor of
Burrill Hall that was formerly occupied by the late Professor Sol Spiegelman, a pioneer
in molecular biology during his years at Urbana-Champaign in the 50s and 60s. Back
then it was the time when the molecular biology revolution started. Now we are fortunate
to be at the beginning of a new era of science and medicine marked by the completion of
the human genome project. We welcome your visit to our laboratory home page and any
inquiry about research collaboration or joining our research efforts at this exciting time of
post-genomic discovery.