Selected Publications
2009:
David Cervantes, Catherine Crosby, Xiang Y. (2009). Arrestin orchestrates cross-talk between GPCRs to
modulate the spatiotemporal activation of ERK MAPK Circulation Research. (in press)
De Arcangelis V, Liu R, Soto D, Xiang Y. (2009) Differential binding of phosphodiesterase 4D isoforms to β2 adrenoceptor in cardiac myocytes" J. Biol. Chem. (published online)
Liu R, Ramani B, Soto D, De Arcangelis V, Xiang Y. (2009) Agonist dose-dependent PKA and GRK phosphorylation regulate β2 adrenoceptor coupling to Gi proteins in cardiomyocytes J. Biol. Chem. (Published online)
Yum K, Na S, Xiang Y, Wang N, Yu
M. (2009) Mechanochemical delivery and dynamic tracking of single
fluorescent quantum dots in Living Cells. Nano letter
9(5):2193-8
Soto D, De Arcangelis V,
Zhang J, Xiang
Y.
(2009)
Dynamic PKA activities induced by
b
adrenoceptors dictate signaling propagation for substrate
phosphorylation and myocyte contraction Circulation Research.
27;104(6):770-9
Zhang HT,
Whisler LR, Huang Y, Xiang Y, O'Donnell JM. (2009) Postsynaptic alpha-2
adrenergic receptor are crticial for the antidepressant-like
desipramine on behavior.Neuropsychopharmacology.
34(4):1067-77
2008:
De Arcangelis V, Soto D, Xiang Y. (2008) Phosphodiesterase 4 and
phosphotase 2A differentially regulate cAMP/PKA signaling for
cardiac myocyte contraction under stimulation of beta1 adrenergic
receptor. Mol Pharmacol.
74(5):1453-62
Wang Y, De
Arcagelis V, Ramali, B, Jung YS, Xiang Y. (2008) Norepinephrine and epinephrine induced distinct
b2 adrenoceptor
signaling is dictated by GRK phosphorylation in cardiomyocytes. J Biol. Chem.
283(4):1799-1807[Download]
2007:
Shcherbakova OG, Hurt CM, Xiang Y, Dell'Acqua ML, Zhang Q, Tsien RW,
Kobilka BK.(2007)
Organization of beta-adrenoceptor signaling compartments by
sympathetic innervation of cardiac myocytes. J Cell Biol. 176(4):521-33.
Download
Sun Y, Huang J, Xiang Y, Bastepe M, Juppner H, Kobilka BK, Zhang JJ, and Huang X.
(2007) Dosage-dependent switch from G
protein-coupled to G protein-independent signaling by a GPCR. The
EMBO Journal. 26(1):53-64
Download.
Wang Y,
Lauffer B, Von Zastrow M, Kobilka B, Xiang Y. (2007) NSF
Regulates {beta}2 Adrenoceptors Trafficking and Signaling in
Cardiomyocytes. Mol
Pharmacol. 72(2):429-439
Download
Selected papers before 2005:
Xiang Y, Naro F, Zoudilova M, Jin SL, Conti M, and Kobilka BK.
(2005) PDE4D is
required for Beta2AR subtype-specific signaling in cardiac myocytes. PNAS. 102(3): 909-14. Download
Xiang Y and Kobilka B. (2003) The PDZ-binding motif of the beta 2 adrenoceptor is essential for
physiologic signaling and trafficking in cardiac myocytes. PNAS. 100: 10776-10781. Download
Xiang Y and Kobilka B. (2003) Myocyte Adrenoceptor Signaling Pathways. Science,
300: 1530-1532. Download
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