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The GPCR Group

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Selected Publications


Xiang YK. (2011) Compartalization of beta adrenergic Signals in Cardiomyocytes. Circulation Research (in press)

Jain A, Liu R, Ramani B, Arauz E, Ishitsuka Y, Ragunathan K, Park J, Chen J, Xiang KY*, and Ha J*. (2011) Probing Cellular Protein Complexes via Single Molecule Pull-down. Nature (in press), * corresponding authors.

He Y, Kapoor A, Cook S, Liu S, Xiang KY, Rao CV, Kenis P, and Wang F. (2011) The non-receptor tyrosine kinase Lyn controls neutrophil adhesion by recruiting the CrkL/C3G complex to and activating Rap1 at the leading edge. J Cell Sci (in press).

Liu S, Zhang J, Xiang YK. (2011) FRET-based direct detection of dynamic protein kinase A activity on the sarcoplasmic reticulum in cardiomyocytes. Biochem Biophys Res Commun. 14;404(2):581-6

Yum K, Yu MF, Wang N, Xiang YK. (2011) Biofunctionalized nanoneedles for the direct and site-selective delivery of probes into living cells. Biochim Biophys Acta. 1810(3):330-8.

Wang D, De Arcangelis V, Ruijie Liu, Xiang Y. (2011) Amyloid β dimer induces β2 adrenergic receptor internalization and desensitization J. Biol. Chem. (revision)


David Cervantes, Catherine Crosby, Xiang Y. (2010). Arrestin orchestrates cross-talk between GPCRs to modulate the spatiotemporal activation of ERK MAPK Circulation Research. 106;79-88

Sellers ZM, De Arcangelis V, Xiang Y, and Best PM (2010) Cardiomyocytes with disrupted CFTR function require CaMKII and Ca2+-activated Cl- channel activity to maintain contraction rate. J. Physiology. 588(Pt 13):2417-29

De Arcangelis V, Liu SB, Zhang D, Soto D, and Xiang Y. (2010) Equilibrium between adenylyl cyclase and phosphodiesterase patterns adrenergic agonist dose-dependent spatiotemporal cAMP/PKA activities in cardiomyocytes.Mol Pharmacol 78(3):340-9

Wang D, Govindaiah, Liu R, Skarpiak B, De Arcangelis V, Cox CL, Xiang Y. (2010) Amyloid β dimer activates β2 adrenergic receptor and induces PKA dependent AMPA receptor hyperactivity. FASEB J 24(9):3511-21


De Arcangelis V, Liu R, Soto D, Xiang Y. (2009) Differential binding of phosphodiesterase 4D isoforms to β2 adrenoceptor in cardiac myocytes. J. Biol. Chem.284(49):33824-32

Liu R, Ramani B, Soto D, De Arcangelis V, Xiang Y. (2009) Agonist dose-dependent PKA and GRK phosphorylation regulate β2 adrenoceptor coupling to Gi proteins in cardiomyocytes. J. Biol. Chem. 284(47): 32353-8

Yum K, Na S, Xiang Y, Wang N, Yu M. (2009) Mechanochemical delivery and dynamic tracking of single fluorescent quantum dots in Living Cells. Nano Letter. 9(5):2193-8

Soto D, De Arcangelis V, Zhang J, Xiang Y. (2009) Dynamic PKA activities induced by beta adrenoceptors dictate signaling propagation for substrate phosphorylation and myocyte contraction. Circulation Research. 27;104(6):770-9


Zhang HT, Whisler LR, Huang Y, Xiang Y, O'Donnell JM. (2009) Postsynaptic alpha-2 adrenergic receptor are crticial for the antidepressant-like desipramine on behavior.Neuropsychopharmacology. 34(4):1067-77


De Arcangelis V, Soto D, Xiang Y. (2008) Phosphodiesterase 4 and phosphotase 2A differentially regulate cAMP/PKA signaling for cardiac myocyte contraction under stimulation of beta1 adrenergic receptor.Mol Pharmacol. 74(5):1453-62 

Wang Y, De Arcagelis V, Ramali, B, Jung YS, Xiang Y. (2008)  Norepinephrine and epinephrine induced distinct b2 adrenoceptor signaling is dictated by GRK phosphorylation in cardiomyocytes.J. Biol. Chem. 283(4):1799-1807[Download]


Shcherbakova OG, Hurt CM, Xiang Y, Dell'Acqua ML, Zhang Q, Tsien RW, Kobilka BK.(2007) Organization of beta-adrenoceptor signaling compartments by sympathetic innervation of cardiac myocytes.J. Cell Biology.  176(4):521-33. Download

Sun Y,  Huang J, Xiang Y,  Bastepe M, Juppner H,  Kobilka BK, Zhang JJ, and Huang X. (2007) Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR. The EMBO Journal.  26(1):53-64 Download.

Wang Y, Lauffer B, Von Zastrow M, Kobilka B, Xiang Y. (2007) NSF Regulates {beta}2 Adrenoceptors Trafficking and Signaling in Cardiomyocytes.Mol Pharmacol.  72(2):429-439 Download


Selected papers before 2005:

Xiang Y, Naro F, Zoudilova M, Jin SL, Conti M, and Kobilka BK. (2005) PDE4D is required for Beta2AR subtype-specific signaling in cardiac myocytes. PNAS.  102(3): 909-14. Download

Xiang Y  and  Kobilka B. (2003) The PDZ-binding motif of the beta 2 adrenoceptor is essential for physiologic signaling and trafficking in cardiac myocytes. PNAS.  100: 10776-10781. Download

Xiang Y and Kobilka B. (2003) Myocyte Adrenoceptor Signaling Pathways. Science, 300: 1530-1532. Download


Click here for more publications from our current and previous research.



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Kevin Xiang (kevinyx@illinois.edu)
Last updated: Oct., 2009

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