exploring
mammalian
evo-devo
developing
new model
systems
Integrating
diverse
approaches

Limb

evo-devo

We seek to determine the developmental processes that have been modified to produce new limb forms, and the degree to which the nature of these processes biases limb evolution.

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sensory
adaptations

We seek to identify the main biological forces in the genome, during development, and in anatomy that promote the success of species in adapting to their changing environments.

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biomedical
applications

We seek to use newly established mammalian model species as "natural mutants" to illuminate the genomic and developmental basis of human congenital malformations and teratogenesis.

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sears is named next president of PAN-AM sedb

Dr. Sears has been named the president of the pan-american society for evolutionary developmental biology, the new evo-devo society of the americas.

Sears Lab receives NSF Dimensions grant

The Sears lab has received a grant from the NSF dimensions of biodiversity program to study the "genomic and developmental basis of sensory adaptations."

Sears Lab receives NSF Dev systems grant

the sears lab has received a grant from the developmental systems cluster of NSF IOS to study the "genetic determinants of mammalian limb diversity"

Sears lab mission

Organismal form is the product of a complex suite of interacting developmental processes. Variation in these processes allows mammals to adapt to changing environments, but also generates congenital malformations in humans. Developmental variation therefore presents a unifying concept for evolutionary biology and biomedicine, whose understanding is critical to the success of both fields. Our primary research goals are to determine how developmental variation within a species produces congenital malformations in humans, and among species generates new evolutionary forms in mammals.