MCB 450
Introductory Biochemistry
School of Molecular & Cellular Biology
University of Illinois at Urbana-Champaign
rlalt@life.illinois.edu
course home page course contact University of Illinois

 
Course Syllabus and Readings Assignments

  SYLLABUS Fall 2017

Lecture

Date

Topic

Lecturer

Chapter

1

Tu, Jan 16

Introduction; Covalent Bonds; Stereochemistry; Functional Groups; Biomolecules; Cell Organization

Orlean

 1, 2 (pgs  24-26)

2

Th, Jan 18

Water; Non-Covalent Intermolecular Interactions; H-bonds, Ionization of Weak Acids & Bases; Titrations; pH

Orlean

 2

3

Tu, Jan 23

Amino Acids: Properties & Ionization; Peptides; Protein Secondary Structure

Orlean

3-4

4

Th, Jan 25

Protein Structure; Protein Folding & Denaturation

Orlean

 4

5

Tu, Jan 30

Protein Purification; Chromatographic Strategies; Electrophoresis; Peptide Sequencing; X-ray Crystallography

Orlean

 5

6

Th, Feb 1

Carbohydrate Structure; Glycosidic Bonds

Orlean

 10

7

Tu, Feb 6

Polysaccharides & Glycoproteins

Orlean

 10

Review

Th, Feb 8

Optional Review

Orlean

  

Exam I

Th, Feb 8

Exam I - 7 - 9 pm

Orlean

 1-5 + 10

8

Tu, Feb 13

Fatty Acids, Lipids & Membranes

Orlean

 11-12

9

Th, Feb 15

Membrane Structure & Function; Membrane Proteins

Orlean

 12

10

Tu, Feb 20

Equilibria; Principles of Enzyme Catalysis

Orlean

 6

11

Th, Feb 22

Enzyme Kinetics I: V, Km, Vmax, Kcat

Orlean

 7-sections 1 & 2

12

Tu, Feb 28

Enzyme Kinetics II: Enzyme Inhibition; Enzyme Mechanisms

Orlean

 8
13

Th, Mar 1

Allostery; Enzyme Regulation; Hemoglobin & O2-binding

Orlean

 Chapter 7-section 3; Chapter 9

14

Tu, Mar 6

Principles of metabolism; ATP and high-energy compounds;  electron carriers

Fratti

 15

Review

Th, Mar 8

Optional Review

Orlean

 
Exam II

Th, Mar 8

Exam II - 7 - 9 pm

Orlean

 6-9, 11-12
15

Tu, Mar 13

Glycolysis

Fratti

 16
16

Th, Mar 15

Gluconeogenesis

Fratti

 17
17

Tu, Mar 27

Pentose Phosphate Pathway

Fratti

 26
18

Th, Mar 29

The Pyruvate Dehydrogenase Complex and the Krebs cycle

Fratti

 18-19
19

Tu, Apr 3

The Electron Transport Chain; redox potential; ROS

Fratti

 20

Review

Th, Apr 5

Optional Review

Fratti

  

Exam III

Th, Apr 5

Exam III - 7-9pm

Fratti

 15-20, 26
20

Tu, Apr 10

The ATP synthase; uncouplers; NADH shuttles

Fratti

21
21

Th, Apr 12

Fatty acid synthesis; β-oxidation; ketone bodies

Fratti

 27-28
22

Tu, Apr 17

Nitrogenous bases; nucleic acid composition and structure

Fratti

 33
23

Th, Apr 19

Replication

Fratti

 33-34
24

Tu, Apr 24

Transcription; lac operon regulation

Fratti

 36
25

Th, Apr 26

RNA processing; the genetic code; tRNAs; wobble hypothesis; tRNA synthetase

Fratti

 38-39

26

Tu, May 1

Ribosome structure; Protein synthesis; Mutations

Fratti

 39-40

Tues, May 8

FINAL EXAM (8:00 am to 11:00am)

Fratti  20-21, 27-28, 33-34,  36, 38-41