MCB 450
Introductory Biochemistry
School of Molecular & Cellular Biology
University of Illinois at Urbana-Champaign
rlalt@life.illinois.edu
course home page course contact University of Illinois

 
Course Syllabus and Readings Assignments

  SYLLABUS Fall 2017

Lecture

Date

Topic

Lecturer

Chapter

1

Tu, Aug 29

Introduction; Covalent Bonds; Stereochemistry; Functional Groups; Biomolecules; Cell Organization

Orlean

 1, 2 (pgs  24-26)

2

Th, Aug 31

Water; Non-Covalent Intermolecular Interactions; H-bonds, Ionization of Weak Acids & Bases; Titrations; pH

Orlean

 2

3

Tu, Sept 5

Amino Acids: Properties & Ionization; Peptides; Protein Secondary Structure

Orlean

3-4

4

Th, Sept 7

Protein Structure; Protein Folding & Denaturation

Orlean

 4

5

Tu, Sept 12

Protein Purification; Chromatographic Strategies; Electrophoresis; Peptide Sequencing; X-ray Crystallography

Orlean

 5

6

Th, Sept 14

Carbohydrate Structure; Glycosidic Bonds

Orlean

 10

7

Tu, Sept 19

Polysaccharides & Glycoproteins

Orlean

 10

Review

Th, Sept 21

Optional Review

Orlean

  

Exam I

Th, Sept 21

Exam I - 7 - 9 pm

Orlean

 1-5 + 10

8

Tu, Sept 26

Fatty Acids, Lipids & Membranes

Orlean

 11-12

9

Th, Sept 28

Membrane Structure & Function; Membrane Proteins

Orlean

 12

10

Tu, Oct 3

Equilibria; Principles of Enzyme Catalysis

Orlean

 6

11

Th, Oct 5

Enzyme Kinetics I: V, Km, Vmax, Kcat

Orlean

 7-sections 1 & 2

12

Tu, Oct 10

Enzyme Kinetics II: Enzyme Inhibition; Enzyme Mechanisms

Orlean

 8
13

Th, Oct 12

Allostery; Enzyme Regulation; Hemoglobin & O2-binding

Orlean

 Chapter 7-section 3; Chapter 9

14

Tu, Oct 17

Principles of metabolism; ATP and high-energy compounds;  electron carriers

Fratti

 15

Review

Th, Oct 19

Optional Review

Orlean

 
Exam II

Th, Oct 19

Exam II - 7 - 9 pm

Orlean

 6-9, 11-12
15

Tu, Oct 24

Glycolysis

Fratti

 16
16

Th, Oct 26

Gluconeogenesis

Fratti

 17
17

Tu, Oct 31

Pentose Phosphate Pathway

Fratti

 26
18

Th, Nov 2

The Pyruvate Dehydrogenase Complex and the Krebs cycle

Fratti

 18-19
19

Tu, Nov 7

The Electron Transport Chain; redox potential; ROS

Fratti

 20

Review

Th, Nov 9

Optional Review

Fratti

  

Exam III

Th, Nov 9

Exam III - 7-9pm

Fratti

 15-20, 26
20

Tu, Nov 14

The ATP synthase; uncouplers; NADH shuttles

Fratti

21
21

Th, Nov 16

Fatty acid synthesis; β-oxidation; ketone bodies

Fratti

 27-28
22

Tu, Nov 28

Nitrogenous bases; nucleic acid composition and structure

Fratti

 33
23

Th, Nov 30

Replication

Fratti

 33-34
24

Tu, Dec 5

Transcription; lac operon regulation

Fratti

 36
25

Th, Dec 7

RNA processing; the genetic code; tRNAs; wobble hypothesis; tRNA synthetase

Fratti

 38-39

26

Tu, Dec 12

Ribosome structure; Protein synthesis; Mutations

Fratti

 39-40

Mon, Dec 18

FINAL EXAM (8:00 am to 11:00am)

Fratti  27-28, 33-34,  36, 38-41