ID #1206

For the mitochondrial proteins that need to be imported into the mitochondria from the cytoplasm, there is a pre-sequence on the protein to signal it to be transported to the mitochondrion, but are there pre-sequences that signal the proteins to be embedded in the inner or outer membranes? What makes them be embedded?

Great question. Yes, there will need to be a secondary signal of some sort (the primary signal being the presequence that got the protein to the mitochondria to begin with). We haven't covered the concept yet of inserting a protein into a membrane, but we're about two or three lectures away from that. Once we cover that material, you'll be able to apply what we learn then to how an ETC protein might end up in the inner mitochondrial membrane. The concept will be the same, although the specific signal will of course be different.

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