Nucleo-Cytoplasmic Exchange

ID #1210

I was looking through my notes and I wanted to clarify a question I had. Importin shuttles a protein into the nucleus via the nuclear pore complex correct? So, does this mean importin shuttles the protein to the nuclear pore complex which then recognizes it and allows it to pass into the nucleus? Or importin shuttles the protein to the nucleus and the protein just has to go through the nuclear pore complex to get into the nucleus? Let me know if this question is too confusing or doesn't make any sense.

I think what you're asking is if the importin goes along with the cargo protein into the nucleus, right? If that's what you're asking, then the answer is yes -- the importin accompanies the cargo molecule, then releases it and goes back out into the cytoplasm to grab the next cargo molecule.

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