DNA Structure and Replication

ID #1792

I have a question about the replication of the lagging strand, is the lagging strand elongated by RNA primase, then DNA poly III, next DNA poly I, and lastly ligase. Or is it as soon as one okazaki fragment is done, DNA poly I joins in, followed by ligase, while other okazaki fragment are still being made?

As soon as DNA polymerase III finishes synthesis of an Okazaki fragment, the fork has moved on and primase is ready to begin the next one. So while the next Okazaki fragment is being worked on, the one you just finished is being "cleaned up" by DNA polymerase I and DNA ligase.

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