DNA Structure and Replication

ID #1787

What specifically do the major and minor grooves indicate in the double helical DNA structure?

The grooves allow physical access to the bases in a double helix, and that's where the actual information is -- in the sequences of bases. So if you're a protein, for example, who is supposed to recognize and bind to a particular sequence in a double helix, you have to be able to "touch" those bases, and it's easier to get into a major groove than it is a minor groove.

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