DNA Structure and Replication

ID #1784

What you we mean by "Base stacking interactions: planar, organic rings are hydrophobic, they stack to minimize contact with water" ?


The nitrogenous base component of a nucleotide is planar (flat) in three dimensions, and it's also hydrophobic. So in a given strand, if you have a G next to an A next to a C and so on, those base components will get very close to each other to minimize their contact with water. This provides stability to the molecule and will mean more energy is needed to separate that strand from a complementary strand which is also hiding its bases inside that double helix.

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