DNA Structure and Replication

ID #1780

Is the only difference between topoisomerase and helicase is that topiosomerase has the capability to unwind and seal DNA, while helicase can only unzip? Additionally, is helicase only found in eurkaryotes and topiosomerase in prokaryotes?

Actually, topoisomerases and helicases (with different names and slightly different mechanisms) can be found in both prokaryotes and eukaryotes. The fundamental difference between the two is that helicases separate strands without cutting and resealing the strands, while topoisomerases cut, twist (or release), and religate the DNA while keeping the strands together.

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