DNA Structure and Replication

ID #1779

What role the ss-DNA binding protein plays in replication?

One of our overall "rules" to remember in MCB 150 is that if two nucleic acid molecules are complementary to each other and find each other, they will hybridize (form complementary base pairs). So if helicase peels the two strands apart and then moves the replication fork down the line, unless something is specifically done to prevent those parental strands from re-hybridizing, they will do just that, and you will have undone the work that helicase did for you. SSBs bind to the single-stranded DNA, preventing it from re-hybridizing with its "partner."

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