DNA Structure and Replication

ID #1688

I think you described base-stacking interactions as hydrophobic interactions between the bases on each strand to minimize the interaction of these bases with water. If this is correct, can you please explain how disrupting these interactions would denature the DNA?

It's just about accumulating as many stabilizing factors as necessary to hold the strands together. The hydrogen bonds and hydrophobic interactions aren't individually very strong, but over the length of a chromosome, they provide more than enough stabilization to hold the helix together.

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