DNA Structure and Replication

ID #1133

Where does DNA polymerase I get the energy to remove RNA nucleotides and replace them with DNA nucleotides?

Removing an RNA base is a hydrolyis reaction, which means it's exergonic. And replacing it with a DNA base uses the same energy source that any synthesis reaction uses -- the hydrolysis of the pyrophosphate group from the incoming nucleotide (in this case, a deoxyribonucleoside triphosphate).

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