DNA Structure and Replication

ID #2235

Is hybridization just the adding of the first base in DNA replication? Meaning only primase can hybridize a base?

Hybridization refers to the ability of complementary DNA bases to come together. So A will hybridize with T, and C will hybridize with G. 

This applies to the entire strand of a DNA molecule, as well. For example, if a double stranded molecule of DNA is exposed to heat so that the strands denature (come apart) the two single strands can pair up again as all the T-A basepairs and G-C basepairs come back together. 

Hybridization lets primase and polymerases know which base belongs in a given position - only the complementary base will "fit" perfectly. So hybridization is part of adding the first base - but every other base added must also hybridize correctly before it will be added to the growing DNA molecule. 

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