DNA Structure and Replication

ID #2230

After listening to your lecture on Chromatin structure I came across you making a point of, "the beads are positively charged to give the negatively charged DNA so give the DNA a 'happy place' to be rung around." This concept makes perfect sense to me, but I am confused on how these basic proteins can be positively charged. If you're basic, aren't you given a negative charge? I just need some help understanding that concept, thanks.

The charge of a histone protein is positive because histone proteins are made up of many basic amino acids. It may be helpful to look back to lecture 5  to see the basic amino acids and their positive charges. Remember in that lecture that Prof Mehrtens talked about physiological pH being 7 and at that pH a base has already done its job as a proton acceptor, so it is positively-charged.

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