DNA Structure and Replication

ID #1116

If for example a sequence is written 5'-G-A-C-T-C-A-G-3', does that mean that it has to anneal starting with its 5' end? Or can it anneal at whichever end will make it antiparallel to another strand, either starting at 5' end or 3' end?

The 5' end of one nucleic acid strand anneals with the 3' end of another strand, provided the bases are complementary. Whatever makes it antiparallel and complementary works!

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