DNA Structure and Replication

ID #1109

I was wondering what the function of the non-histone proteins are in chromatin. I know you mentioned this in class, but I think I was writing something down and missed it. Also, how exactly do you differentiate between chromatin and a chromosome, is the difference simply that when chromatin really becomes condensed and coiled it becomes a chromosome?

There are lots of other proteins peripherally involved with chromatin remodeling, but they're not histones. Anything that fits into this category would be termed a non-histone protein that is still under the category of chromatin, although we're not going to mention any of them specifically in this class.

As far as the difference between chromosomes and chromatin, it's kind of an arbitrary hierarchy. DNA and protein are organized into chromatin, and chromatin is coiled, folded, etc. into a chromosome. Chromatin is a more general term, while a chromosome is a unique molecule of chromatin (DNA and protein). You have lots and lots of chromatin in your nuclei, but you only have 46 chromosomes. See the difference?

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