DNA Structure and Replication

ID #2071

Why does an increase in temperature result in breakdown of hydrogen bonds in A-T rich regions of DNA first?

Remember that A-T and C-G are both bonded by hydrogen bonds, but A-T has 2 and C-G has 3. Thus A-T bonds are denatured by less heat since there are less bonds, but yes they are same type of bonds.

It's not about the strength of the bonds, it's the nubmer of the bonds. A region with more A-T base pairs will simply denature faster than a region with more C-G pairs because there are fewer bonds holding it together.

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