Energy and Metabolism

ID #1678

What prevents the Krebs Cycle from occurring in the absense of oxygen?

It's a function of one of the enzymes being common to Krebs cycle and the ETC. The molecule is succinate dehydrogenase, and it's the molecule that FAD is covalently attached to when it gets reduced to FADH2. It's also what we've been referring to as Complex II. So if the terminal electron acceptor is removed (i.e. no oxygen), the ETC backs up such that succinate dehydrogenase cannot reduce FAD, which in turn shuts down the Krebs cycle.

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