Energy and Metabolism

ID #1668

Why does the NADH from glycolysis produce 2 ATP each whereas that from the TCA cycle produce 3 ATP each?


NADH produces 2 ATP from glycolysis because we first must donate 2 ATP to fuel glycolysis. By the end of glycolysis, we have created 4 ATP molecules, a net gain of 2 ATP molecules. In the TCA cycle, NADH produces 3 ATP. However, if you look on the slides from earlier, Professor Mehrtens said that it takes ATP to move NADH to the matrix of the mitochondria from the cytoplasm so we lose 1 ATP per NADH molcule, so the net of NADH from the TCA cycle then becomes 2 per NADH molecule.

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