Energy and Metabolism

ID #2211

In class I believe it was mentioned that a negative regulator and a non competitive inhibitor would be used interchangeably. The description of a negative inhibitor is that it slows down enzyme activity. I thought a non-competitive inhibitor would completely shut down enzyme activity. Are they really the same thing? They seem to have slightly different definitions.


I think you may be thinking of an irreversible inhibitor, rather than a non-competitive one. Irreversible inhibitors are compounds that a cell does not expect to see, and they can completely and permanently shut down the enzyme that they bind to. A non-competitive inhibitor, if you recall the lecture about enzymes, binds to an allosteric site of an enzyme, and prevents that enzyme from interacting with its natural substrate as long as the non-competitive inhibitor is bound.

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