Energy and Metabolism

ID #2118

In the textbook there is a figure which describes the H+/pyruvate symporter. I understand that an acetyl group is attached to a CoA via pyruvate dehydrogenase. But what happens to the pyruvate as it enters through the symporter at the inner membrane into the matrix? I see that there is an H+ involved but not sure how it affects the pyruvate.


A symporter is a channel through a biomembrane that moves two or more
molecules or ions in the same direction. In this case, both pyruvate and a
proton are brought into the matrix of the mitochondria. Nothing actually
happens to the pyruvate until it is in the matrix, which is when pyruvate
dehydrogenase converts pyruvate into acetyl-CoA. This step is not really
considered part of the Krebs Cycle.

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