Nucleic Acid Structure and General Features

ID #2195

Are there two phosphodiester linkages between each sugar in a nucleic acid? One connecting each sugar to a side of the phosphate? Or is that only considered a single phosphodiester linkage?


A phosphodiester linkage forms between two different nucleotide monomers. A bond forms between the 3'OH group the sugar of one monomer and the 5' phosphate of the incoming monomer, and this is called a phosphodiester linkage. I'm not entirely sure that this is what you described in the second part of your question since I'm not sure if you are talking one monomer or two. A slide from your lecture 7 notes illustrates the formation of a phosphodiester linkage between two nucleotides.

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