Nucleic Acid Structure and General Features

ID #2096

Can you please explain why thymidine triphosphate isn't considered a common, biologically relevant molecule?

The molecule you're asking about would be represented TTP, right? And if there's no "d" in front of the letters, it is understood without being stated that the sugar is ribose and not deoxyribose. In other words, the terminology rNTP is meaningless; we'd simply use NTP. Now you should ask yourself if RNA, which would be incorporating NTPs, would use thymine. As we've discussed in class, the pyrimidines found in RNA are C and U, but not T. So while dTTP would be a molecule that could be incorporated into DNA, TTP is not a molecule that would be incorporated into RNA, and would therefore not be a relevant molecule in biology.

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