Proteins and Enzymes

ID #1625

Our notes say that covalent bonding is rare in proteins, but isn't there covalent bonding at the primary structure?

Yes the peptide bonds of the primary structure are all covalent bonds; your notes refer to tertiary structure, in which covalent disulfide bonding is rare. This is because cysteine is the only amino acid that can participate in such a bond and it is rare that any two of them would line up in the way necessary to complete the bond. Of course, that's not to say it doesn't happen.

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