Proteins and Enzymes

ID #1620

For sickle cell mutation to occur, does the Glu have to change to Val in one or in both beta chains of the hemoglobin?

This is the difference between being a carrier for the disease and having the full-blown disorder. A carrier has one wild-type gene and one mutated gene for beta globin, and therefore is making some good beta-globin and some mutated. But for any given molecule of hemoglobin, both of its beta chains need to be wild-type.

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