Proteins and Enzymes

ID #1614

I don’t understand why increasing the concentration of the natural substrate wouldn’t disrupt irreversible inhibitors. I know that the enzyme can’t be “rescued”, but as natural substrate concentration increases, wouldn’t the probability that the irreversible inhibitor will find an “open” enzyme decrease.

No, that's not the way it works. Since the irreversible inhibitor isn't in competition with the natural substrate for the active site, the molecules of inhibitor just go about their business inactivating the enzymes one at a time until they're all inactive, regardless of how many or how few substrate molecules are around. Yes, it's true that at any moment in time an active enzyme might bind a substrate and catalyze the reaction, but it's only a matter of time before it's "found" by an inhibitor molecule.

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