Proteins and Enzymes

ID #1044

I was wondering that by lowering the activation energy barrier is the enzyme altering the overall free energy?


No, the overall change in free energy, or delta G, is the difference in energy level between reactant and product. It does not take into account how you might have to travel to get there. A good analogy using totally made up and most likely incorrect numbers is this: Let's say Las Vegas is at 2000 ft above sea level, and Los Angeles is at zero. If you're driving from Vegas to LA, you'll definitely climb higher than 2000 ft on the way, but that doesn't change the elevations of the cities, does it? The difference in elevations (energy levels in this analogy) is the same no matter what it takes to get from one to the other.

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