Genetic Regulation and the Lactose Operon

ID #1410

Could you explain to me how a bacterial cell regulates the rate of translation. In the notes, it discusses that the cell can control particular tRNA species. How so?


You'll discuss many other levels of regulation in more detail in MCB 250, including this type, but I'll give you a quick example. For amino acids that a cell can make on its own, in bacteria it shouldn't come as a surprise that the genes for biosynthesis of a given amino acid are found in operons. If the cell turns down expression of a given amino acid biosynthetic pathway, there's less of that amino acid around, which means in turn that less of it will be charged to tRNA molecules by that aminoacyl tRNA synthetase. This then means less of that amino acid to incorporate into protein.

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