Microtubules

ID #1564

How is it that Taxol stabilizes the "dynamic instability" in a given cell? Does it bind to tubulin like vincristine or vinblastine? Further, what consequence does this hold for the cell? It seems that a cell wouldn't be equipped to cope with something so "unnatural". Will the cell live indefinately provided we keep introducing taxol into the cellular environmnet?


Actually, taxol reaches the same end as vincristine or vinblastine, but by different means. Instead of "hiding" tubulin and inducing depolymerization, it binds to MTs and prevents them from reorganizing. Either way, that cell will never complete M-phase, which means it will not divide. Any cell that is arrested long enough (when it wasn't supposed to be) will eventually die, so if the drug is administered regularly enough, the problematic cells can be eliminated.

Print this record Print this record
Send to a friend Send to a friend
Show this as PDF file Show this as PDF file
Export as XML-File Export as XML-File