ID #1336

Earlier in the FAQ you answered a question and said that the alpha GTP binding site is blocked when the dimer is created, I have in my notes however that the GTP binds to both, are my notes incorrect or are there special circumstances etc...? Also you said that the alpha subunit binding site is never hydrolyzed; does this mean that there is a GTP in the alpha subunit that is trapped, or does it mean that there never was or will be a GTP there?

The alpha tubulin does get a GTP bound to its nucleotide binding site, and then has a beta tubulin subunit sit right on top of it. So yes, there is a GTP in there, but no, it does not get hydrolyzed.

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