ID #1316

Is there a major difference between the drugs binding to the free tublin or the free tublin binding to the drugs...I know that Colchicine blocks microtubule assembly...but does the process matter as long as something gets binded. I am also confused on the difference between free tublin and microtubule ends.

Fundamentally, there's no difference between the drug binding to the dimer or the dimer binding to the drug. The end result is the same -- it cannot be added to the end of a microtubule. And the free tubulin represents the building blocks that can get incorporated into a microtubule, whereas the microtubule end represents where the most recent dimers just got incorporated.

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