Microtubules

ID #1311

In our lecture notes, it says that the beta tubulin polypeptide is hydrolyzed, but I have written in another area that the alpha and beta both have binding sites. Does this mean that the beta one is the only one used?


Yes, I don't know if I stated this explicitly, but your observation is right on. Both the alpha and beta subunits of a tubulin dimer have a nucleotide binding site, but when the dimer comes together, it "blocks" the GTP binding site on the alpha subunit, so it never gets hydrolyzed.

Print this record Print this record
Send to a friend Send to a friend
Show this as PDF file Show this as PDF file
Export as XML-File Export as XML-File