Microtubules

ID #2167

After the dyneins moving along cilia or flagella and reaching the end of the (-) end, where will they go next?


They will only move as far toward the minus end as allowed by the dynein which is closest to the basal body. After that, they just stop, rather than fall off. This is why the axoneme bends instead of collapsing altogether. It's unknown what gets them to release and reset, but they have to do this in order to be able to bend around the circle each subsequent time. Prior to bending, the dyneins are just anchored into the A-tubules of one doublet, reaching their head groups out to try to contact a nearby microtubule. What they find to bind to is the B-tubule of the adjacent doublet.

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