Actin and Myosin

ID #1960

Does ADP-actin only bind to the minus end of actin or does ATP-actin bind and then hydrolyze right away?


Actually, none of the above. ADP-actin doesn't have enough of an affinity for a filament to be added. And the reason that the pointed end seems to have all ADP-actin isn't because the ATPs got hydrolyzed immediately, it's because it takes so much more for a G-actin monomer to be added to this end that the probability is that the last one added will have the time to hydrolyze its ATP before the next one gets added. That's why depolymerization is faster at the pointed end.

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