Actin and Myosin

ID #1875

When Myosin is bound to actin, is it necessary for there to be ADP in the binding site, or would that make the Myosin-Actin bond beaker than it would be if there was nothing at all in the binding site? Essentially, if we do an experiment where we remove all ATP except for enough for one myosin movement, when the head was done moving and was bound to the actin, would we find ADP in the myosin binding site or nothing at all?

Once the power stroke is finished, the ADP is lost from the nucleotide binding site, and when this happens, the myosin tightens its "grip" on the actin. Not only that, if the ADP didn't leave, a new ATP wouldn't be able to bind and continue the cycle.

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