Actin and Myosin

ID #1571

In the rigor mortis conformation, there is firm attachment of myosin to the actin filament, and there is no ATP attached to the myosin. Is there ADP on the actin filament, as we discussed on Friday's lecture?

Yes, it's important to separate the need for ATP/ADP on the actin filament itself from what is in the nucleotide binding site of the myosin. They are totally separate and distinct. So yes, that particular G-actin molecule in the F-actin filament almost certainly has ADP in its nucleotide binding site, regardless of what might be in the myosin.

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