Actin and Myosin

ID #2468

Under normal circumstances is there any one side of actin (pointed end or barbed end) that is going to polymerize more than the other?


I am assuming by "normal conditions" you mean if neither end of the filament is bound by a protein cap. If you meant something else, please clarify. 
But yes, if both ends are free, then there will be a difference. The critical concentration will always be lower at the plus (barbed) end, meaning that it takes fewer available G actin to add an actin there. This makes it easier to polymerize at the plus end. 
The critical concentration will always be higher (meaning it will take more available actin) to add an actin at the minus (pointed) end. 

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