ID #1965

I was wondering where the proton pumps for the lysosomes/endosomes come from.

The answer to this question is one of those great "connect the dots" opportunities. What is a proton pump? It's a transmembrane protein complex. And where do transmembrane proteins get their start? In the RER! These pumps would be packaged together in the Golgi and then sent out to fuse with new endocytic vesicles or existing endosomes.

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