Lysosomes

ID #1587

How are proton pumps incorporated into the membrane of the early endosome (it seems unlikely that the endosome would have translocons to insert transmembrane proteins)?


That's a good assumption about not having translocons in an endosome. So the question becomes (or more accurately, returns to) how does any transmembrane protein get inserted into the membrane? They come through the ER, get processed in the Golgi, and get sent to the proper location. And if you'll recall, endosomes are one of the potential destinations for cargo exiting the trans-Golgi. In lecture, I focused on traffic to the late endosome, but the Golgi also sends proton pumps--already inserted into the membrane--to the early endosomes.

Print this record Print this record
Send to a friend Send to a friend
Show this as PDF file Show this as PDF file
Export as XML-File Export as XML-File