ID #1586

I think you said that the lower pH in the late endosome triggers the mannose-6-phosphate receptores to release the acid hydrolases. What triggered the signal receptors from the plasma membrane to release the signal molecules in the early endosome?

Same concept, just a different pH. Recall that the pH of even an early endosome is acidic, just not as acidic as it's going to get. By the way, this has nothing to do with our lecture content or the exam tomorrow, but this change in pH has been "adopted" by a number of viruses to escape from the endocytic vesicles they are "captured" in. Viruses are fascinating, and we'll be taking a look at some of their "strategies" for replicative cycles later in the semester.

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