ID #1304

I'm not understanding what you wrote in an earlier posting about the "combination of mannose-6-P and mannose-6-P receptors." What I understand from that is each endosome/lysosome has a specific signal for an acid hydrolase. But how does the endosome say "Hey, I've got nucleic acid in here" to the golgi apparatus? Does the vesicle containing certain hydrolases go looking for the endosome's signal, or does the endosome send a signal to the golgi?

No, that's not what I was trying to suggest; sorry for the confusion. The question I was trying to answer with that statement was if there were other receptors in the trans Golgi that recognized signals that directed traffic elsewhere, and the answer is yes. A mannose-6-P group will only get you to an endosome/lysosome, but there are other signals that will get you to the plasma membrane, for example. That's all I was trying to say with that.

But as I said before, there's no way that the cell can anticipate (or be told) what needs to be degraded in a lysosome, so it makes the full suite of hydrolases and uses what it needs.

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