Lysosomes

ID #1301

Can you briefly explain lysosomal storage disorders?


A lysosomal storage disorder is caused by a deficiency in one of the acid hydrolases in a lysosome. Glucocerebrosidase is an enzyme found in a lysosome. A person who has Gaucher's disease (one of the 45 known lysosomal storage disorders) is lacking functional glucocerebrosidase. This causes accumulations of non-degraded products, and interferes with normal cell metabolism, and eventually in tissue function. The most commonly affected tissues are nervous tissue, so these storage disorders usually present as nervous disorders.

Print this record Print this record
Send to a friend Send to a friend
Show this as PDF file Show this as PDF file
Export as XML-File Export as XML-File