Lysosomes

ID #2455

I was just curious as to what UDP stands for when you're creating a M6P signal. uracil diphosphate? i don't know. Also, why is it that you add an N-acetylglucosamine in addition to this phosphate, which then just gets chopped off?


I believe the UDP is uridine diphosphate. Based on the figure in the lecture notes, it looks like the N-acetylglucosamine is attached to the phosphate in UDP, so to transfer a phosphate to the mannose the N-acetylglucosamine comes along for the ride. I don't know exactly why the cell does it that way, but the N-actylglucosamine is not required for signaling that an acid hydrolase should be targeted to the lysosome so it gets chopped off. 

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