Endoplasmic Reticulum

ID #1989

Is it the C-terminal sequence of a transmembrane that gets cleaved and replaced by the GPI anchor. What does the cleaving? signal peptidase? Where does the oligosaccharide come from and how does it know to replace part of the transmembrane?


Yes. It's about 25-30 amino acids at the C-terminus of the protein that serve no function in the finished protein, they only serve to anchor the protein in place until that "tail" can be cleaved and the "new" C-terminus of the protein covalently linked to your GPI anchor.

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